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KMID : 1151820220160020141
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Journal of the Korean Society of Radiology
2022 Volume.16 No. 2 p.141 ~ p.150
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Effect on Physiological Metabolism of Calcium Ion at Cell Membrane Model of Parathyroid which Irradiated by High Energy X-ray
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Ko In-Ho
Yeo Jin-Dong
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Abstract
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The initial co-transport and counter-transport permeate transport characteristics of calcium ion at epithelial cell membrane model in parathyroid which irradiated by high energy x-ray(linac 6 MV) was investigated. The epithelial cell membrane model used in this experiment was a polysulfonated copolymerized membrane of poly(PS-DVB: polystyrene-divinylbenzene). The difference of sorbed water in membrane, fixed carrier concentration(SO32-), initial pH value, OH- concentration were occurred at difference of Ca2+concentration and quantity of parathyroid hormone, respectively. The initial co-transport and counter-transport permeate flux of Cl-, OH-, Ca2+on fixed carrier concentration(SO32-) and initial pH value of irradiated membrane was found to be decreased than non-irradiated membrane. The initial co-transport and counter-transport permeate flux of Ca2+ on fixed carrier concentration (SO32-), initial pH value, OH- concentration in irradiated membrane were found to be decreased about 2.68 ∼ 6.87 times, about 1.42 ∼ 1.63 times, about 2.07 ∼ 1.672 times than non-irradiated membrane, respectively. As a result, the quantity of parathyroid hormone was decreased at irradiated membrane than non-irradiated membrane. The decrease of parathyroid hormone was occurred at hypoparathyroidism and osteoporosis, parathyroiditis, and so on. As the parathyroid hormone in epithelial cell membrane model were abnormal, cell damages were appeared at cell.
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KEYWORD
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High Energy X-ray, Fixed Carrier Concentration(SO32-), Sulfonated Copolymerized Membrane(PS-DVB), Calcium Ion
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